The pomegranate is a relatively tolerant crop. Yet, in intensive cropping 30-50% of the total running expenses relate to crop protection. Even so a final 10-50% of the marketable yield is lost because of various damages. Special attention should be given at the pre planting stage testing for soil pathogens which may affect the crop much later when control would be impractical. Then the planting material should be carefully chosen for freedom of pathogens which might be introduced into the field by planting. After planting, a special interaction is needed between agro technical means and pathogen/pest direct control to minimize yield loss.

Although direct control is based, for the most part on chemical control, new, future procedures may reduce the use of chemicals and even enable the use of 'organic' culture.